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pentobarbital will lessen the level or impact of colchicine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.pentobarbital will lessen the level or effect of tofacitinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of. Lack of, or diminished response to tofacitinib may manife